In 1997, Chicago's Lady Mondegreen were about to be come the next great rock band. That is, until they're lead singer Nick was found dead of an overdose. Reeling from the loss of their band and their friend, bassist Cass and drummer Greg had no choice but to pick up the pieces and move on. 20 years later, in anniversary of their major label debut, Cass and Greg reunite for a hometown show, joined by Nick's now-grown daughter Priscilla, stepping into her dad's place. As they wait backstage, aided by a PA named Carla, reminiscence turns to unresolved grief and buried resentments, threatening to derail the show before it begins. Moving back and forth through time, Isolated in the Light deconstructs the rock star myth, while celebrating the power that music can have.