After all her cancer treatments fail, Elena Harris seeks out her estranged sister Shana as a match for a bone marrow transplant. More than years separate the two sisters whose lives have taken them far from their Protestant childhood in Missouri. A desperate Elena reluctantly visits her sister’s inner-city apartment where they play a late-night spades game haunted by their past. A month later, Shana’s arrives just in time for Shabbat dinner at her sister’s Georgetown home. Her arrival offers hope for Elena’s future and potential redemption for Shana. In the end, the price for Shana’s help will cost the entire family. Marrow Deep is inspired by the playwright’s life and family.