The F and L at 1330 takes place in the year 2010 in Chicago, in one of the many areas of the city that is going drastic change in the form of gentrification. As old established businesses go down, new condos and upscale businesses take their place. One of the last places left in a near North Side neighborhood is Fernando and Lalo's, an unassuming bar located at 1330 Dayton Ave. It is run by CARLA and BERNARDO, the son and daughter of Fernando (by different mothers) and the niece and nephew of Lalo. They are assisted by CARLA's daughter, ELENA.
With the sounds of redevelopment providing a constant backdrop, CARLA contemplates leaving the bar business and the constant headache it creates in trying to compete with the trendier options aimed at the new residents. Meanwhile, BERNARDO still revels in the idea of being a business owner and is anxious to try new ways of bringing in nw customers. And despite her career path, ELENA is just as eager to keep the bar in the family, seeing it as a tradition and a family legacy.
As outside forces - local government, hungry developers and indifferent new residents - push in from the outside and threaten the future of the bar, CARLA makes the decision to sell the F&L while the time is right. This much to the dismay of BERNARDO, who refuses to go along with her decision. Their fight uncovers several secrets that threatens to change all of their relationships to the bar and each other.