21st century newlyweds Allie and Maggie have just moved into an old house that's been in the family for generations, where Vesta, a young bride-to-be (and frustrated intellectual) of the 19th century, lives in that house with her parents. Through the quantum vagaries of time, Allie and Vesta become visible to one another, past and future co-existing in a small parlor room. While multiple souls echo across time, resonating with alternate versions of themselves, Allie teaches Vesta of modern female emancipation, changing the lives of both women in the process.

Helen Pario slaves in her laboratory, shutting out family and friends, in an attempt to discipline her mind and avoid her grief. She has no idea why her lover and colleague, Sam, killed himself, and the only solace she now seeks is that of finishing his life’s work. Sam was intent on creating the first artificial cell, a primitive lifeform, and thereby becoming godlike himself. In her fixation, Helen also tries ignores the fact that Sam had created a more ordinary life: she’s pregnant with his child. While Helen’s sister, Sarah, tries to get Helen to engage more with life-as-we-know-it, Sam’s graduate student, Chuck, helps Helen pursue her obsession with life-in-a-dish. As scientific success dawns, Helen increasingly detaches herself from all the lives and deaths around her, and is ultimately forced to ask whether a hypothetical life form in a petrie dish has greater value than the "mundane" lives of Sam and her child.  And if it does, then how valuable is any living human?

Five relationships navigate hairpin turns, with some approaching the end of their run, while others are embarking on new adventures. In the chaos of love, some grow stronger while others retreat. Whether they experience entrapment or liberation, whether they blurt out the truth or cling to the lies, at the end of this difficult, neurotic, hilarious meal, no one is quite the same.

Like an appetizer that doesn’t quite satisfy, Claire and William discover that their youthful passion can’t sustain them through the daily grind of adulthood.

And much as one might regret his choice of entree, Edgar questions his choice not to be a real father to Sophie. Sophie, meanwhile, learns she doesn’t much care for dinner dates with Dad.

Grace is sorely tempted by novelty, and struggles to remain faithful to both her “usual” (the linguine), and her husband (Nick). Rebecca wants to try, possibly to take, whatever Grace is having, be it her entree or her husband. Nick will take whatever basic comforts, food or women, are offered to him, while James longs for the adventure represented by Grace... and the sturgeon. This foursome is a tangled mess of indecision, insecurity and mis-aligned loyalties.

Above it all ride Patrick and Lily, whose neuroses mask a surprisingly functional relationship. But are they ready for the next step -- parenthood? What are they giving up? What if their kid hates them? Despite the insanity swirling around them, this is their time to mincingly edge towards the precipice and reaffirm that whatever dish gets served up next, the meal is a good one.

A mayfly couple tries to fill their lives with action, meaning, pleasure, and serenity — all within their allotted 24 hours.

What happens when an every-man (or woman) attempts to trick fate, and stack the cosmic deck in her favor? Upon narrowly missing a traffic accident, Anna, a comfortable, perhaps complacent, suburbanite, faces the realization that we are one fluke away from tragedy, every moment of our lives. Therefore, she reasons, we must likewise be one fluke from bliss. With that in mind, she launches a campaign to entice chance to be on her side, to create “positive random events.” Anna narrowly keeps ahead of the law while her husband tries to cope with her assault on karma, and her friends try to stop it. The universe, however, refuses to cooperate, with each of Anna’s effort ending more disastrously than the last: as ever, chance remains indifferent to her preferences.