Two men in the Alaskan tundra search for woolly mammoth tusks as an alternative to elephant ivory. But their most recent discovery causes their employer to pivot from the ivory trade to a more technologically innovative venture as a means of combating climate change. Inspired by the real-life founding of Colossal Biosciences, The Tusk Hunters explores the morality of de-extinction and the toll that scientifically revolutionary ideas take on those who execute them.